1510 Estrogen promotes stabilization of lymphatic vasculature with cooperation of apelin

We have previously demonstrated that both acute and chronic skin inflammation induced by UVB-irradiation resulted in dysfunction of lymphatic capillaries, indicating a critical role function the homeostasis. Recently, we been investigating how morphological alteration capillaries human affects its aging disease. Notably, confirmed significant structural impairment female over 45 years old which can be associated with age-related loss hormones. Meanwhile, number studies shown declining estrogen level women has negative effects on skin. Like this, although importance noticed regulation circulatory system physiology, their relevance functional mechanism is still poorly understood. To investigate direct effect vessels, first expression receptors including ERβ GPR30 endothelial cells (LECs). When LECs were treated major endogenous estrogen, 17β-estradiol (E2), cellular proliferation was promoted LEC hyperpermeability blocked. These results suggested E2 signaling induce lymphangiogenesis while enhancing integrity. Interestingly, co-stimulation low-dose apelin, reported as promoter for vascular integrity, synergistically stabilized disrupted intercellular junction whereas single stimulation or apelin did not. Taken together, strong protective integrity potential target to enhance this without inducing even condition estrogen.